Unknown

Dataset Information

0

MiR-429 mediates tumor growth and metastasis in colorectal cancer.


ABSTRACT: Colorectal cancer (CRC), presenting the third most common malignancy worldwide. In recent years, the aberrantly upregulation or downregulation of miRNAs in CRC have been evidenced in a number of studies. In this study, our results showed that the expression of miR-429 was significantly higher in CRC tissue compared with adjacent non-tumor tissue. In addition, our findings showed that miR-429 level was significantly associated with clinicoplathological features and prognosis of patients with CRC. Moreover, our findings showed that miR-429 exerted oncogenic effect by directly targeting HOXA5, a transcription factor of HOX families that is involved in the development and progression of CRC.

SUBMITTER: Han Y 

PROVIDER: S-EPMC5336497 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

altmetric image

Publications

miR-429 mediates tumor growth and metastasis in colorectal cancer.

Han Yantao Y   Zhao Qian Q   Zhou Jie J   Shi Rui R  

American journal of cancer research 20170201 2


Colorectal cancer (CRC), presenting the third most common malignancy worldwide. In recent years, the aberrantly upregulation or downregulation of miRNAs in CRC have been evidenced in a number of studies. In this study, our results showed that the expression of miR-429 was significantly higher in CRC tissue compared with adjacent non-tumor tissue. In addition, our findings showed that miR-429 level was significantly associated with clinicoplathological features and prognosis of patients with CRC.  ...[more]

Similar Datasets

| S-EPMC5385833 | biostudies-literature
| S-EPMC4650731 | biostudies-other
| S-EPMC5856798 | biostudies-literature
| S-EPMC4123095 | biostudies-literature
| S-EPMC5491908 | biostudies-other
| S-EPMC4973316 | biostudies-literature
| S-EPMC4694830 | biostudies-other
| S-EPMC4780435 | biostudies-literature
| S-EPMC3756000 | biostudies-literature
| S-EPMC4359968 | biostudies-literature