Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC5338333 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yang Jing J Jin Xin X Yan Yuqian Y Shao Yingjie Y Pan Yunqian Y Roberts Lewis R LR Zhang Jun J Huang Haojie H Jiang Jingting J
Scientific reports 20170306
Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers in the world. Elevated glucose metabolism in the availability of oxygen, a phenomenon called the Warburg effect, is important for cancer cell growth. Fructose-1,6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis and is frequently lost in various types of cancer. Here, we demonstrated that expression of FBP1 was downregulated in HCC patient specimens and decreased expression of FBP1 associated with poor ...[more]