Ontology highlight
ABSTRACT:
SUBMITTER: Shen K
PROVIDER: S-EPMC5302942 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Shen Kaikai K Xi Zhichao Z Xie Jianling J Wang Hua H Xie Chanlu C Lee C Soon CS Fahey Paul P Dong Qihan Q Xu Hongxi H
Oncotarget 20160801 35
Hepatocellular carcinoma (HCC) is an aggressive malignancy and the 5-year survival rate of advanced HCC is < 10%. Guttiferone K (GUTK) isolated from the Garcinia genus inhibited HCC cells migration and invasion in vitro and metastasis in vivo without apparent toxicity. Proteomic analysis revealed that actin-binding protein profilin 1 (PFN1) was markedly increased in the presence of GUTK. Over-expression of PFN1 mimicked the effect of GUTK on HCC cell motility and metastasis. The effect of GUTK o ...[more]