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Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens.

ABSTRACT: Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-sectional study comparing the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ LTART) from Mexico using 16S ribosomal RNA (16sRNA) targeted sequencing. These individuals were on two ART regimens based on either Non-Nucleoside Reverse Transcriptase Inhibitors (EFV) or ritonavir-boosted Protease Inhibitors (PI) with the same backbone of Nucleoside Reverse Transcriptase Inhibitors. Microbiome diversity was reduced in treated HIV infection compared to HIV SN (p?

SUBMITTER: Pinto-Cardoso S

PROVIDER: S-EPMC5338340 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens.

Pinto-Cardoso Sandra S Lozupone Catherine C Briceño Olivia O Alva-Hernández Selma S Téllez Norma N Adriana Aguilar A Murakami-Ogasawara Akio A Reyes-Terán Gustavo G

Scientific reports 20170306

Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-sectional study comparing the fecal microbiomes of HIV-uninfected (HIV SN) to HIV-infected individuals on long-term ART (HIV+ LTART) from Mexico using 16S ribosomal RNA (16sRNA) targe ...[more]

PMID: 28262770

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