Ontology highlight
ABSTRACT:
SUBMITTER: Falk S
PROVIDER: S-EPMC5338691 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Falk Sven S Bugeon Stéphane S Ninkovic Jovica J Pilz Gregor-Alexander GA Postiglione Maria Pia MP Cremer Harold H Knoblich Jürgen A JA Götz Magdalena M
Neuron 20170201 4
The developmental mechanisms regulating the number of adult neural stem cells (aNSCs) are largely unknown. Here we show that the cleavage plane orientation in murine embryonic radial glia cells (RGCs) regulates the number of aNSCs in the lateral ganglionic eminence (LGE). Randomizing spindle orientation in RGCs by overexpression of Insc or a dominant-negative form of Lgn (dnLgn) reduces the frequency of self-renewing asymmetric divisions while favoring symmetric divisions generating two SNPs. Im ...[more]