Ontology highlight
ABSTRACT:
SUBMITTER: Clemens RA
PROVIDER: S-EPMC533979 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Clemens Regina A RA Newbrough Sally A SA Chung Elaine Y EY Gheith Shereen S Singer Andrew L AL Koretzky Gary A GA Peterson Erik J EJ
Molecular and cellular biology 20041201 24
PML-retinoic acid receptor alpha (RARalpha) regulated adaptor molecule 1 (PRAM-1) is an intracellular adaptor molecule that is upregulated during the induced granulocytic differentiation of promyelocytic leukemic cells and during normal human myelopoiesis. This report describes the generation of PRAM-1-deficient mice and an analysis of the function of this adaptor in neutrophil differentiation and mature neutrophil function. We demonstrate here that neutrophil differentiation is not impaired in ...[more]