Ontology highlight
ABSTRACT:
SUBMITTER: Locke MN
PROVIDER: S-EPMC6400565 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Locke Melissa N MN Thorner Jeremy J
The Journal of cell biology 20181221 3
Target of rapamycin complex-2 (TORC2), a conserved protein kinase complex, is an indispensable regulator of plasma membrane homeostasis. In budding yeast (<i>Saccharomyces cerevisiae</i>), the essential downstream effector of TORC2 is protein kinase Ypk1 and its paralog Ypk2. Muk1, a Rab5-specific guanine nucleotide exchange factor (GEF), was identified in our prior global screen for candidate Ypk1 targets. We confirm here that Muk1 is a substrate of Ypk1 and demonstrate that Ypk1-mediated phosp ...[more]