Ontology highlight
ABSTRACT:
SUBMITTER: Han X
PROVIDER: S-EPMC5339836 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Cell research 20170127 3
Recent advances have demonstrated the power of small molecules in promoting cellular reprogramming. Yet, the full potential of such chemicals in cell fate manipulation and the underlying mechanisms require further characterization. Through functional screening assays, we find that mouse embryonic fibroblast cells can be induced to trans-differentiate into a wide range of somatic lineages simultaneously by treatment with a combination of four chemicals. Genomic analysis of the process indicates a ...[more]