Ontology highlight
ABSTRACT:
SUBMITTER: Vallaster MP
PROVIDER: S-EPMC5340528 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Vallaster Markus P MP Kukreja Shweta S Bing Xin Y XY Ngolab Jennifer J Zhao-Shea Rubing R Gardner Paul D PD Tapper Andrew R AR Rando Oliver J OJ
eLife 20170214
Paternal environmental conditions can influence phenotypes in future generations, but it is unclear whether offspring phenotypes represent specific responses to particular aspects of the paternal exposure history, or a generic response to paternal 'quality of life'. Here, we establish a paternal effect model based on nicotine exposure in mice, enabling pharmacological interrogation of the specificity of the offspring response. Paternal exposure to nicotine prior to reproduction induced a broad p ...[more]