Hereditary Persistence of Alpha-Fetoprotein Is Associated with the -119G>A Polymorphism in AFP Gene.
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ABSTRACT:
SUBMITTER: Deshpande N
PROVIDER: S-EPMC5340718 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Hereditary Persistence of Alpha-Fetoprotein Is Associated with the -119G>A Polymorphism in <i>AFP</i> Gene.
Deshpande Neha N Chavan Radhika R Bale Govardhan G Avanthi Urmila Steffie US Aslam Mohsin M Ramchandani Mohan M Reddy D Nageshwar DN Ravikanth V V VV
ACG case reports journal 20170301
Alpha-fetoprotein (AFP) is a glycoprotein that is produced by the liver and yolk sac during fetal development. Its levels are usually raised in malignant conditions. Hereditary persistence of AFP (HPAFP) is a rare benign condition with elevated levels of AFP. It is inherited in a dominant mode with complete penetrance and is usually not associated with any clinical disability. We report two individuals with elevated levels of AFP harboring the -119G>A polymorphism in the <i>AFP</i> gene. A genet ...[more]
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