Ontology highlight
ABSTRACT:
SUBMITTER: Roden C
PROVIDER: S-EPMC5340965 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Roden Christine C Gaillard Jonathan J Kanoria Shaveta S Rennie William W Barish Syndi S Cheng Jijun J Pan Wen W Liu Jun J Cotsapas Chris C Ding Ye Y Lu Jun J
Genome research 20170113 3
Mature microRNAs (miRNAs) are processed from hairpin-containing primary miRNAs (pri-miRNAs). However, rules that distinguish pri-miRNAs from other hairpin-containing transcripts in the genome are incompletely understood. By developing a computational pipeline to systematically evaluate 30 structural and sequence features of mammalian RNA hairpins, we report several new rules that are preferentially utilized in miRNA hairpins and govern efficient pri-miRNA processing. We propose that a hairpin st ...[more]