Ontology highlight
ABSTRACT:
SUBMITTER: Weitz SH
PROVIDER: S-EPMC3918773 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Weitz Sara H SH Gong Ming M Barr Ian I Weiss Shimon S Guo Feng F
Proceedings of the National Academy of Sciences of the United States of America 20140121 5
DiGeorge syndrome critical region gene 8 (DGCR8) is the RNA-binding partner protein of the nuclease Drosha. DGCR8 and Drosha recognize and cleave primary transcripts of microRNAs (pri-miRNAs) in the maturation of canonical microRNAs (miRNAs) in animals. We previously reported that human, frog, and starfish DGCR8 bind heme when expressed in Escherichia coli and that Fe(III) heme activates apoDGCR8 in reconstituted pri-miRNA processing assays. However, the physiological relevance of heme in miRNA ...[more]