Ontology highlight
ABSTRACT:
SUBMITTER: Kimani SG
PROVIDER: S-EPMC5341070 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Kimani Stanley G SG Kumar Sushil S Bansal Nitu N Singh Kamalendra K Kholodovych Vladyslav V Comollo Thomas T Peng Youyi Y Kotenko Sergei V SV Sarafianos Stefan G SG Bertino Joseph R JR Welsh William J WJ Birge Raymond B RB
Scientific reports 20170308
TAM receptors (Tyro-3, Axl, and Mertk) are a family of three homologous type I receptor tyrosine kinases that are implicated in several human malignancies. Overexpression of TAMs and their major ligand Growth arrest-specific factor 6 (Gas6) is associated with more aggressive staging of cancers, poorer predicted patient survival, acquired drug resistance and metastasis. Here we describe small molecule inhibitors (RU-301 and RU-302) that target the extracellular domain of Axl at the interface of t ...[more]