Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5341102 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Li Hongyuan H Liu Xin X Wang Dan D Su Liangping L Zhao Tingting T Li Zhongwei Z Lin Cong C Zhang Yu Y Huang Baiqu B Lu Jun J Li Xiaoxue X
Scientific reports 20170308
In C. elegans, the transcription factor skinhead-1 (SKN-1), the ortholog of human NF-E2-related factor 2 (Nrf-2), plays important roles in oxidative stress defense and aging processes. It has been documented that the activity of SKN-1 is regulated by its phosphorylation modification. However, whether other posttranslational modifications of SKN-1 affect its function remains unclear to date. Here we report, for the first time, that SKN-1 is O-GlcNAcylated at Ser470 and Thr493 by O-GlcNActransfera ...[more]