Ontology highlight
ABSTRACT:
SUBMITTER: Nishikawaji T
PROVIDER: S-EPMC5341872 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nishikawaji Taketo T Akiyama Yoshimitsu Y Shimada Shu S Kojima Kazuyuki K Kawano Tatsuyuki T Eishi Yoshinobu Y Yuasa Yasuhito Y Tanaka Shinji S
Oncotarget 20161001 41
SETDB2 is a histone H3 lysine 9 (H3K9) tri-methyltransferase that is involved in transcriptional gene silencing. Since it is still unknown whether SETDB2 is linked to carcinogenesis, we studied alterations and functions of SETDB2 in human gastric cancers (GCs). SETDB2 protein was highly expressed in 30 of 72 (41.7%) primary GC tissues compared with their normal counterparts by immunohistochemistry. SETDB2 overexpression was significantly associated with the late stage of GCs (P<0.05) and poor pr ...[more]