Ontology highlight
ABSTRACT:
SUBMITTER: Willemen Y
PROVIDER: S-EPMC5342027 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Willemen Yannick Y Van den Bergh Johan M J JM Bonte Sarah M SM Anguille Sébastien S Heirman Carlo C Stein Barbara M H BM Goossens Herman H Kerre Tessa T Thielemans Kris K Peeters Marc M Van Tendeloo Viggo F I VF Smits Evelien L J EL Berneman Zwi N ZN
Oncotarget 20161101 45
We formerly demonstrated that vaccination with Wilms' tumor 1 (WT1)-loaded autologous monocyte-derived dendritic cells (mo-DCs) can be a well-tolerated effective treatment in acute myeloid leukemia (AML) patients. Here, we investigated whether we could introduce the receptor for hyaluronic acid-mediated motility (RHAMM/HMMR/CD168), another clinically relevant tumor-associated antigen, into these mo-DCs through mRNA electroporation and elicit RHAMM-specific immune responses. While RHAMM mRNA elec ...[more]