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Cytoplasmic vacuolization in cell death and survival.


ABSTRACT: Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known morphological phenomenon observed in mammalian cells after exposure to bacterial or viral pathogens as well as to various natural and artificial low-molecular-weight compounds. Vacuolization often accompanies cell death; however, its role in cell death processes remains unclear. This can be attributed to studying vacuolization at the level of morphology for many years. At the same time, new data on the molecular mechanisms of the vacuole formation and structure have become available. In addition, numerous examples of the association between vacuolization and previously unknown cell death types have been reported. Here, we review these data to make a deeper insight into the role of cytoplasmic vacuolization in cell death and survival.

SUBMITTER: Shubin AV 

PROVIDER: S-EPMC5342458 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Cytoplasmic vacuolization in cell death and survival.

Shubin Andrey V AV   Demidyuk Ilya V IV   Komissarov Alexey A AA   Rafieva Lola M LM   Kostrov Sergey V SV  

Oncotarget 20160801 34


Cytoplasmic vacuolization (also called cytoplasmic vacuolation) is a well-known morphological phenomenon observed in mammalian cells after exposure to bacterial or viral pathogens as well as to various natural and artificial low-molecular-weight compounds. Vacuolization often accompanies cell death; however, its role in cell death processes remains unclear. This can be attributed to studying vacuolization at the level of morphology for many years. At the same time, new data on the molecular mech  ...[more]

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