Ontology highlight
ABSTRACT:
SUBMITTER: Ohoka N
PROVIDER: S-EPMC5448626 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Ohoka Nobumichi N Nagai Katsunori K Shibata Norihito N Hattori Takayuki T Nara Hiroshi H Cho Nobuo N Naito Mikihiko M
Cancer science 20170426 5
We previously developed a hybrid small molecule SNIPER (Specific and Nongenetic IAP-dependent Protein ERaser) against transforming acidic coiled-coil-3 (TACC3), SNIPER(TACC3), that induces proteasomal degradation of TACC3 protein. In this study, we found that SNIPER(TACC3) induces cytoplasmic vacuolization derived from endoplasmic reticulum (ER) and paraptosis-like cell death selectively in cancer cells. Mechanistic analysis suggests that accumulation of ubiquitylated protein aggregates that req ...[more]