Ontology highlight
ABSTRACT:
SUBMITTER: Giese M
PROVIDER: S-EPMC5342690 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Giese Madleen M Turiello Nadine N Molenda Nicole N Palesch David D Meid Annika A Schroeder Roman R Basilico Paola P Benarafa Charaf C Halatsch Marc-Eric ME Zimecki Michal M Westhoff Mike-Andrew MA Wirtz Christian Rainer CR Burster Timo T
Oncotarget 20161101 46
Major histocompatibility complex (MHC) class I molecules present antigenic peptides to cytotoxic T cells. During an adaptive immune response, MHC molecules are regulated by several mechanisms including lipopolysaccharide (LPS) and interferon gamma (IFN-g). However, it is unclear whether the serine protease cathepsin G (CatG), which is generally secreted by neutrophils at the site of inflammation, might regulate MHC I molecules. We identified CatG, and to a higher extend CatG and lactoferrin (LF) ...[more]