Ontology highlight
ABSTRACT:
SUBMITTER: Ross-Adams H
PROVIDER: S-EPMC5342698 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Oncotarget 20161101 46
Two independent regions within HNF1B are consistently identified in prostate and ovarian cancer genome-wide association studies (GWAS); their functional roles are unclear. We link prostate cancer (PC) risk SNPs rs11649743 and rs3760511 with elevated HNF1B gene expression and allele-specific epigenetic silencing, and outline a mechanism by which common risk variants could effect functional changes that increase disease risk: functional assays suggest that HNF1B is a pro-differentiation factor tha ...[more]