Ontology highlight
ABSTRACT:
SUBMITTER: Yoshioka Y
PROVIDER: S-EPMC5342720 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Yoshioka Yuichiro Y Suzuki Takehiro T Matsuo Yo Y Nakakido Makoto M Tsurita Giichiro G Simone Cristiano C Watanabe Toshiaki T Dohmae Naoshi N Nakamura Yusuke Y Hamamoto Ryuji R
Oncotarget 20161101 46
AKT1 is a cytosolic serine/threonine kinase that is overexpressed in various types of cancer and has a central role in human tumorigenesis. Although it is known that AKT1 is post-translationally modified in various ways including phosphorylation and ubiquitination, methylation has not been reported so far. Here we demonstrate that the protein lysine methyltrasnferase SMYD3 methylates lysine 14 in the PH domain of AKT1 both in vitro and in vivo. Lysine 14-substituted AKT1 shows significantly lowe ...[more]