Ontology highlight
ABSTRACT:
SUBMITTER: Fluegen G
PROVIDER: S-EPMC5342902 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Fluegen Georg G Avivar-Valderas Alvaro A Wang Yarong Y Padgen Michael R MR Williams James K JK Nobre Ana Rita AR Calvo Veronica V Cheung Julie F JF Bravo-Cordero Jose Javier JJ Entenberg David D Castracane James J Verkhusha Vladislav V Keely Patricia J PJ Condeelis John J Aguirre-Ghiso Julio A JA
Nature cell biology 20170123 2
Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we report that hypoxic HNSCC and breast primary tumour microenvironments displayed upregulation of key dormancy (NR2F1, DEC2, p27) and hypoxia (GLUT1, HIF1α) genes. Analysis of solitary DTCs in PDX and transgenic mice revealed that post-hypoxic DTCs were frequently NR2F1<sup>hi</sup>/DEC2<sup>hi</sup>/p27<sup>hi</sup>/TG ...[more]