Proteomics

Dataset Information

0

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy


ABSTRACT: Analysis of bone marrow stroma and MVNs via LC-MS/MS.

OTHER RELATED OMICS DATASETS IN: GSE119153

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Kirk Hansen  

LAB HEAD: Kirk C. Hansen

PROVIDER: PXD012002 | Pride | 2020-05-26

REPOSITORIES: Pride

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Publications


The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume that this is because the majority of DTCs are quiescent. Here, we challenge this notion and provide evidence that the microenvironment of DTCs protects them from chemotherapy, independent of cell cycle status. We show that chemoresi  ...[more]

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