Ontology highlight
ABSTRACT:
SUBMITTER: Choi AH
PROVIDER: S-EPMC5344257 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Choi Audrey H AH O'Leary Michael P MP Fong Yuman Y Chen Nanhai G NG
Biomedicines 20160802 3
Oncolytic viruses (OVs) demonstrate the ability to replicate selectively in cancer cells, resulting in antitumor effects by a variety of mechanisms, including direct cell lysis and indirect cell death through immune-mediate host responses. Although the mechanisms of action of OVs are still not fully understood, major advances have been made in our understanding of how OVs function and interact with the host immune system, resulting in the recent FDA approval of the first OV for cancer therapy in ...[more]