Ontology highlight
ABSTRACT:
SUBMITTER: Varadi A
PROVIDER: S-EPMC5344672 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20160902 18
Natural products found in Mitragyna speciosa, commonly known as kratom, represent diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing opportunities to better understand opioid pharmacology. Herein, we report the pharmacology and SAR studies both in vitro and in vivo of mitragynine pseudoindoxyl (3), an oxidative rearrangement product of the corynanthe alkaloid mitragynine. 3 and its corresponding corynantheidine analogs show promise as potent analgesic ...[more]