Ontology highlight
ABSTRACT:
SUBMITTER: Zuiderweg ER
PROVIDER: S-EPMC5344757 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Biomolecular NMR assignments 20161003 1
Hsc70 is the constitutively expressed mammalian heat shock 70 kDa (Hsp70) cytosolic chaperone. It plays a central role in cellular proteostasis and protein trafficking. Here, we present the backbone and methyl group assignments for the 386-residue nucleotide binding domain of the human protein. This domain controls the chaperone's allostery, binds multiple co-chaperones and is the target of several classes of known chemical Hsp70 inhibitors. The NMR assignments are based on common triple resonan ...[more]