Association of SCN10A Polymorphisms with the Recurrence of Atrial Fibrillation after Catheter Ablation in a Chinese Han Population.

ABSTRACT: The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage disequilibrium (LD) with the AF-associated SNP rs6800541. In this study, we investigated whether rs6795970 polymorphisms are associated with AF recurrence after catheter ablation. A total of 502 consecutive patients with AF who underwent catheter ablation were included. AF recurrence was defined as a documented episode of any atrial arrhythmias lasting ?30?s after a blanking period of 3 months. AF recurrence was observed between 3 and 12 months after catheter ablation in 24.5% of the patients. There was a significant difference in the allele distribution (p?=?7.86?×?10-5) and genotype distribution (p?=?1.42?×?10-5) of rs6795970 between the AF recurrence and no recurrence groups. In a multivariate analysis, we identified the following independent predictors of AF recurrence: the rs6795970 genotypes in an additive model (OR 0.36, 95%CI 0.22~0.60, p?=?7.04?×?10-5), a history of AF ?36 months (OR 3.57, 95%CI 2.26~5.63, p?=?4.33?×?10-8) and left atrial diameter (LAD) ?40?mm (OR 1.85, 95%CI 1.08~3.19, p?=?0.026). These data suggest that genetic variation in SCN10A may play an important role in predicting AF recurrence after catheter ablation in the Chinese Han population.

SUBMITTER: Wu H 

PROVIDER: S-EPMC5345091 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature