Association of KCNE1 genetic polymorphisms with atrial fibrillation in a Chinese Han population.

ABSTRACT:

Objective

The purpose of this study was to investigate the association of the polymorphisms of the KCNE1 gene with atrial fibrillation (AF) in a Chinese Han population.

Methods

Three hundred seven AF patients and 330 age- and sex-matched controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method for two single-nucleotide polymorphisms (rs1805127 and rs1892593) of the human KCNE1 gene.

Results

The frequencies of the AA, AG, and GG genotypes of rs1805127 were 11.7%, 50.0%, and 43.3%, respectively, in the AF group, whereas the ones in the control group had frequencies of 19.4%, 44.9%, and 35.8%, respectively. There were significant differences in frequencies of these three genotypes (χ(2)=7.820, p=0.016) and G allele (65.8

SUBMITTER: Yao J 

PROVIDER: S-EPMC3483044 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature