Ontology highlight
ABSTRACT:
SUBMITTER: Shi S
PROVIDER: S-EPMC5345346 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Shi Sixiang S Xu Cheng C Yang Kai K Goel Shreya S Valdovinos Hector F HF Luo Haiming H Ehlerding Emily B EB England Christopher G CG Cheng Liang L Chen Feng F Nickles Robert J RJ Liu Zhuang Z Cai Weibo W
Angewandte Chemie (International ed. in English) 20170207 11
Macrocyclic chelators have been widely employed in the realm of nanoparticle-based positron emission tomography (PET) imaging, whereas its accuracy remains questionable. Here, we found that <sup>64</sup> Cu can be intrinsically labeled onto nanographene based on interactions between Cu and the π electrons of graphene without the need of chelator conjugation, providing a promising alternative radiolabeling approach that maintains the native in vivo pharmacokinetics of the nanoparticles. Due to ab ...[more]