Ontology highlight
ABSTRACT:
SUBMITTER: Thi MM
PROVIDER: S-EPMC534550 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Thi Mia M MM Tarbell John M JM Weinbaum Sheldon S Spray David C DC
Proceedings of the National Academy of Sciences of the United States of America 20041115 47
We propose a conceptual model for the cytoskeletal organization of endothelial cells (ECs) based on a major dichotomy in structure and function at basal and apical aspects of the cells. Intracellular distributions of filamentous actin (F-actin), vinculin, paxillin, ZO-1, and Cx43 were analyzed from confocal micrographs of rat fat-pad ECs after 5 h of shear stress. With intact glycocalyx, there was severe disruption of the dense peripheral actin bands (DPABs) and migration of vinculin to cell bor ...[more]