Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC5346032 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Zhang Wenwei W Bu So Young SY Mashek Mara T MT O-Sullivan InSug I Sibai Zakaria Z Khan Salmaan A SA Ilkayeva Olga O Newgard Christopher B CB Mashek Douglas G DG Unterman Terry G TG
Cell reports 20160331 2
Metabolism is a highly integrated process that is coordinately regulated between tissues and within individual cells. FoxO proteins are major targets of insulin action and contribute to the regulation of gluconeogenesis, glycolysis, and lipogenesis in the liver. However, the mechanisms by which FoxO proteins exert these diverse effects in an integrated fashion remain poorly understood. We report that FoxO proteins also exert important effects on intrahepatic lipolysis and fatty acid oxidation vi ...[more]