Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC5346695 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Chen Yansu Y Huang Yefei Y Hou Pingfu P Zhang Zhe Z Zhang Yafei Y Wang Weimin W Sun Guixiang G Xu Lichun L Zhou Jianwei J Bai Jin J Zheng Junnian J
Oncotarget 20161101 48
ING4, a potential tumor suppressor, is implicated in cell cycle arrest, apoptosis, cell migration and angiogenesis. Here, we investigated the clinical value of ING4 and its impact on angiogenesis in colorectal cancer (CRC). In this study, we found that ING4 expression was significantly reduced in CRC tissues versus paired normal colon tissues. Moreover, low ING4 expression was significantly associated with increased lymph node metastasis, advanced TNM stage and poor overall survival. Multivariat ...[more]