Ontology highlight
ABSTRACT:
SUBMITTER: Podszywalow-Bartnicka P
PROVIDER: S-EPMC5346746 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Podszywalow-Bartnicka Paulina P Cmoch Anna A Wolczyk Magdalena M Bugajski Lukasz L Tkaczyk Marta M Dadlez Michal M Nieborowska-Skorska Margaret M Koromilas Antonis E AE Skorski Tomasz T Piwocka Katarzyna K
Oncotarget 20161101 48
Recent studies underscore the role of the microenvironment in therapy resistance of chronic myeloid leukemia (CML) cells and leukemia progression. We previously showed that sustained mild activation of endoplasmic reticulum (ER) stress in CML cells supports their survival and resistance to chemotherapy. We now demonstrate, using dominant negative non-phosphorylable mutant of eukaryotic initiation factor 2 α subunit (eIF2α), that phosphorylation of eIF2α (eIF2α-P), which is a hallmark of ER stres ...[more]