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Radiation-associated circulatory disease mortality in a pooled analysis of 77,275 patients from the Massachusetts and Canadian tuberculosis fluoroscopy cohorts.


ABSTRACT: High-dose ionising radiation is associated with circulatory disease. Risks associated with lower-dose (<0.5?Gy) exposures remain unclear, with little information on risk modification by age at exposure, years since exposure or dose-rate. Tuberculosis patients in Canada and Massachusetts received multiple diagnostic x-ray fluoroscopic exposures, over a wide range of ages, many at doses <0.5?Gy. We evaluated risks of circulatory-disease mortality associated with <0.5?Gy radiation exposure in a pooled cohort of 63,707 patients in Canada and 13,568 patients in Massachusetts. Under 0.5?Gy there are increasing trends for all circulatory disease (n?=?10,209; excess relative risk/Gy?=?0.246; 95% CI 0.036, 0.469; p?=?0.021) and for ischaemic heart disease (n?=?6410; excess relative risk/Gy?=?0.267; 95% CI 0.003, 0.552; p?=?0.048). All circulatory-disease and ischaemic-heart-disease risk reduces with increasing time since exposure (p?

SUBMITTER: Tran V 

PROVIDER: S-EPMC5347030 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Radiation-associated circulatory disease mortality in a pooled analysis of 77,275 patients from the Massachusetts and Canadian tuberculosis fluoroscopy cohorts.

Tran Van V   Zablotska Lydia B LB   Brenner Alina V AV   Little Mark P MP  

Scientific reports 20170313


High-dose ionising radiation is associated with circulatory disease. Risks associated with lower-dose (<0.5 Gy) exposures remain unclear, with little information on risk modification by age at exposure, years since exposure or dose-rate. Tuberculosis patients in Canada and Massachusetts received multiple diagnostic x-ray fluoroscopic exposures, over a wide range of ages, many at doses <0.5 Gy. We evaluated risks of circulatory-disease mortality associated with <0.5 Gy radiation exposure in a poo  ...[more]

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