Ontology highlight
ABSTRACT:
SUBMITTER: Ahn R
PROVIDER: S-EPMC5347092 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Ahn Ryuhjin R Sabourin Valérie V Bolt Alicia M AM Hébert Steven S Totten Stephanie S De Jay Nicolas N Festa Maria Carolina MC Young Yoon Kow YK Im Young Kyuen YK Pawson Tony T Koromilas Antonis E AE Muller William J WJ Mann Koren K KK Kleinman Claudia L CL Ursini-Siegel Josie J
Nature communications 20170309
Tyrosine kinase signalling within cancer cells is central to the establishment of an immunosuppressive microenvironment. Although tyrosine kinase inhibitors act, in part, to augment adaptive immunity, the increased heterogeneity and functional redundancy of the tyrosine kinome is a hurdle to achieving durable responses to immunotherapies. We previously identified the Shc1 (ShcA) scaffold, a central regulator of tyrosine kinase signalling, as essential for promoting breast cancer immune suppressi ...[more]