Ontology highlight
ABSTRACT:
SUBMITTER: Butturini E
PROVIDER: S-EPMC7582491 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Butturini Elena E Carcereri de Prati Alessandra A Mariotto Sofia S
International journal of molecular sciences 20200924 19
STAT1 and STAT3 are nuclear transcription factors that regulate genes involved in cell cycle, cell survival and immune response. The cross-talk between these signaling pathways determines how cells integrate the environmental signals received ultimately translating them in transcriptional regulation of specific sets of genes. Despite being activated downstream of common cytokine and growth factors, STAT1 and STAT3 play essentially antagonistic roles and the disruption of their balance directs ce ...[more]