Ontology highlight
ABSTRACT:
SUBMITTER: Koch MA
PROVIDER: S-EPMC534721 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Koch Marcus A MA Wittenberg Lars-Oliver LO Basu Sudipta S Jeyaraj Duraiswamy A DA Gourzoulidou Eleni E Reinecke Kerstin K Odermatt Alex A Waldmann Herbert H
Proceedings of the National Academy of Sciences of the United States of America 20041117 48
To identify biologically relevant and drug-like protein ligands for medicinal chemistry and chemical biology research the grouping of proteins according to evolutionary relationships and conservation of molecular recognition is an established method. We propose to employ structure similarity clustering of the ligand-sensing cores of protein domains (PSSC) in conjunction with natural product guided compound library development as a synergistic approach for the identification of biologically preva ...[more]