Ontology highlight
ABSTRACT:
SUBMITTER: Pozzi C
PROVIDER: S-EPMC5347543 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20170215 10
X-ray structures of homopolymeric L-ferritin obtained by freezing protein crystals at increasing exposure times to a ferrous solution showed the progressive formation of a triiron cluster on the inner cage surface of each subunit. After 60 min exposure, a fully assembled (μ<sup>3</sup>-oxo)Tris[(μ<sup>2</sup>-peroxo)(μ<sup>2</sup>-glutamato-κ<i>O</i>:κ<i>O</i>')](glutamato-κ<i>O</i>)(diaquo)triiron(III) anionic cluster appears in human L-ferritin. Glu60, Glu61, and Glu64 provide the anchoring of ...[more]