Ontology highlight
ABSTRACT:
SUBMITTER: Shcherbakova A
PROVIDER: S-EPMC5347603 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Shcherbakova Aleksandra A Tiemann Birgit B Buettner Falk F R FF Bakker Hans H
Proceedings of the National Academy of Sciences of the United States of America 20170215 10
Thrombospondin type 1 repeats (TSRs) occur in diverse proteins involved in adhesion and signaling. The two extracellular TSRs of the netrin receptor UNC5A contain WxxWxxWxxC motifs that can be <i>C-</i>mannosylated on all tryptophans. A single <i>C</i>-mannosyltransferase (dumpy-19, DPY-19), modifying the first two tryptophans, occurs in <i>Caenorhabditis elegans</i>, but four putative enzymes (DPY-19-like 1-4, DPY19L1-4) exist in mammals. Single and triple CRISPR-Cas9 knockouts of the three hom ...[more]