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N-Hydroxyimide Ugi Reaction toward ?-Hydrazino Amides.

ABSTRACT: The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to ?-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields. This reaction displays N-N bond formation by cyclic imide migration in the Ugi reaction. Thus, N-hydroxyimide is added as a new acid component in the Ugi reaction and broadens the scaffold diversity.

SUBMITTER: Chandgude AL 

PROVIDER: S-EPMC5348098 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides.

Chandgude Ajay L AL   Dömling Alexander A  

Organic letters 20170221 5

The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields. This reaction displays N-N bond formation by cyclic imide migration in the Ugi reaction. Thus, N-hydroxyimide is added as a new acid component in the Ugi reaction and broadens the scaffold  ...[more]

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