Dataset Information
Aza-Riley Oxidation of Ugi-Azide and Ugi-3CR Products toward Vicinal Tricarbonyl Amides: Two-Step MCR-Oxidation Methodology Accessing Functionalized ?,?-Diketoamides and ?,?-Diketotetrazoles.
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ABSTRACT:
SUBMITTER: Foley C
PROVIDER: S-EPMC6424580 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Aza-Riley Oxidation of Ugi-Azide and Ugi-3CR Products toward Vicinal Tricarbonyl Amides: Two-Step MCR-Oxidation Methodology Accessing Functionalized α,β-Diketoamides and α,β-Diketotetrazoles.
Organic letters 20180221 5
Direct oxidative deamination of glyoxal-derived Ugi-azide and Ugi three-component reaction products readily affords vicinal tricarbonyls (α,β-diketoamides) and α,β-diketotetrazoles with two diversity elements. This significant extension of our previously described multicomponent reaction-oxidative deamination methodology is proposed to proceed through a mechanistically distinct SeO<sub>2</sub>-mediated C-N oxidation derived from an active enol of α-amino-β-ketone systems, effectively an aza-Rile ...[more]