Ontology highlight
ABSTRACT:
SUBMITTER: He F
PROVIDER: S-EPMC5348383 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
He Feng F Chen Huacui H Yang Ping P Wu Qianlong Q Zhang Tong T Wang Chengxing C Wei Jianchang J Chen Zhuanpeng Z Hu He H Li Wanglin W Cao Jie J
Oncotarget 20161201 49
High levels of angiogenesis, metastasis and chemoresistance are major clinical features of colorectal cancer (CRC), a lethal disease with a high incidence worldwide. Aberrant activation of Wnt/β-catenin pathway contributes to CRC progression. However, little is known about regulatory mechanisms of the β-catenin activity in cancer progression. Here we report that Gankyrin was markedly upregulated in primary tumor tissues from CRC patients and was associated with poor survival. Moreover, we demons ...[more]