Ontology highlight
ABSTRACT:
SUBMITTER: Malacaria E
PROVIDER: S-EPMC5349550 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Malacaria Eva E Franchitto Annapaola A Pichierri Pietro P
Scientific reports 20170314
SLX4 is a versatile protein serving as docking for multiple structure-specific endonucleases during DNA repair, however, little is known about its function at demised replication forks. Using RNAi or FA-P cells complemented with SLX4 mutants that abrogate interaction with MUS81 or SLX1, we show that SLX4 cooperates with MUS81 to introduce DSBs after replication stress but also counteracts pathological targeting of demised forks by GEN1. Such unexpected function of SLX4 is unrelated to interactio ...[more]