Ontology highlight
ABSTRACT:
SUBMITTER: Bruck J
PROVIDER: S-EPMC5349589 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Brück Jürgen J Holstein Julia J Glocova Ivana I Seidel Ursula U Geisel Julia J Kanno Toshio T Kumagai Jin J Mato Naoko N Sudowe Stephan S Widmaier Katja K Sinnberg Tobias T Yazdi Amir S AS Eberle Franziska C FC Hirahara Kiyoshi K Nakayama Toshinori T Röcken Martin M Ghoreschi Kamran K
Scientific reports 20170314
The nutritional curcumin (CUR) is beneficial in cell-mediated autoimmune diseases. The molecular mechanisms underlying this food-mediated silencing of inflammatory immune responses are poorly understood. By investigating antigen-specific immune responses we found that dietary CUR impairs the differentiation of Th1/Th17 cells in vivo during encephalomyelitis and instead promoted Th2 cells. In contrast, feeding CUR had no inhibitory effect on ovalbumin-induced airway inflammation. Mechanistically, ...[more]