Ontology highlight
ABSTRACT:
SUBMITTER: Shih VF
PROVIDER: S-EPMC4183330 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Shih Vincent Feng-Sheng VF Cox Jennifer J Kljavin Noelyn M NM Dengler Hart S HS Reichelt Mike M Kumar Pawan P Rangell Linda L Kolls Jay K JK Diehl Lauri L Ouyang Wenjun W Ghilardi Nico N
Proceedings of the National Academy of Sciences of the United States of America 20140908 38
Mammalian hosts are colonized with commensal microbes in various mucosal and epithelial tissues, including the intestinal tract. In mice, the presence of segmented filamentous bacteria (SFB) promotes Th17 differentiation and the development of autoimmune disease. Here, we demonstrate that the IL-23 pathway dynamically regulates the abundance of SFB as well as mucosal barrier function in the adult animal. Genetic or pharmacological inactivation of the pathway selectively perturbs the abundance of ...[more]