Ontology highlight
ABSTRACT:
SUBMITTER: Purushothaman LK
PROVIDER: S-EPMC5349785 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Purushothaman Latha Kallur LK Arlt Henning H Kuhlee Anne A Raunser Stefan S Ungermann Christian C
Molecular biology of the cell 20170118 6
Endosomes are the major protein-sorting hubs of the endocytic pathway. They sort proteins destined for degradation into internal vesicles while in parallel recycling receptors via tubular carriers back to the Golgi. Tubule formation depends on the Rab7/Ypt7-interacting retromer complex, consisting of the sorting nexin dimer (SNX-BAR) and the trimeric cargo selection complex (CSC). Fusion of mature endosomes with the lysosome-like vacuole also requires Rab7/Ypt7. Here we solve a major problem in ...[more]