Ontology highlight
ABSTRACT:
SUBMITTER: Kvainickas A
PROVIDER: S-EPMC6719456 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Kvainickas Arunas A Nägele Heike H Qi Wenjing W Dokládal Ladislav L Jimenez-Orgaz Ana A Stehl Luca L Gangurde Dipak D Zhao Qian Q Hu Zehan Z Dengjel Jörn J De Virgilio Claudio C Baumeister Ralf R Steinberg Florian F
The Journal of cell biology 20190820 9
Retromer is an evolutionarily conserved multiprotein complex that orchestrates the endocytic recycling of integral membrane proteins. Here, we demonstrate that retromer is also required to maintain lysosomal amino acid signaling through mTORC1 across species. Without retromer, amino acids no longer stimulate mTORC1 translocation to the lysosomal membrane, which leads to a loss of mTORC1 activity and increased induction of autophagy. Mechanistically, we show that its effect on mTORC1 activity is ...[more]