Unique epigenetic gene profiles define human breast cancers with poor prognosis.
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ABSTRACT:
SUBMITTER: Pena-Llopis S
PROVIDER: S-EPMC5349877 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Unique epigenetic gene profiles define human breast cancers with poor prognosis.
Peña-Llopis Samuel S Wan Yihong Y Martinez Elisabeth D ED
Oncotarget 20161201 52
Epigenetic enzymes are at the nexus of cellular regulatory cascades and can drive cancer-specific deregulation at all stages of the oncogenic process, yet little is known about their prognostic value in human patients. Here, we used qRT-PCR to profile at high resolution the expression of fifty-five epigenetic genes in over one hundred human breast cancer samples and patient-matched benign tissues. We correlated expression patterns with clinical and histological parameters and validated our findi ...[more]
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