Ontology highlight
ABSTRACT:
SUBMITTER: Hu T
PROVIDER: S-EPMC5349900 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Hu Tao T Chang Ye-Fei YF Xiao Zhangang Z Mao Rui R Tong Jun J Chen Bo B Liu Guang-Cai GC Hong Ying Y Chen Hong-Lan HL Kong Shu-Yi SY Huang Yan-Mei YM Xiyang Yan-Bin YB Jin Hua H
Oncotarget 20161201 52
Ectopic glucose-6-phosphate dehydrogenase (G6PD) expression may contribute to tumorigenesis in cervical cancer associated with high-risk human papillomavirus (HR-HPV 16 and 18) infections. Here, we demonstrate that microRNA-1 (miR-1) in association with AGO proteins targets G6PD in HR-HPV-infected human cervical cancer cells. miR-1 inhibited expression of a reporter construct containing a putative G6PD 3'-UTR seed region and suppressed endogenous G6PD expression. Down-regulation of miR-1 increas ...[more]