MiR-200c Inhibits the Tumor Progression of Glioma via Targeting Moesin.
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ABSTRACT:
SUBMITTER: Qin Y
PROVIDER: S-EPMC5436519 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Publications
MiR-200c Inhibits the Tumor Progression of Glioma via Targeting Moesin.
Qin Yuanyuan Y Chen Weilong W Liu Bingjie B Zhou Lei L Deng Lu L Niu Wanxiang W Bao Dejun D Cheng Chuandong C Li Dongxue D Liu Suling S Niu Chaoshi C
Theranostics 20170410 6
We attempt to demonstrate the regulatory role of miR-200c in glioma progression and its mechanisms behind. Here, we show that miR-200c expression was significantly reduced in the glioma tissues compared to paratumor tissues, especially in malignant glioma. Exogenous overexpression of miR-200c inhibited the proliferation and invasion of glioma cells. In addition, the <i>in vivo</i> mouse xenograft model showed that miR-200c inhibited glioma growth and liver metastasis, which is mainly regulated b ...[more]
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